Differential Diagnosis of Hypogammaglobulinemia
Drug Induced
Antimalarial agents
Captopril
Carbamazepine
Glucocorticoids
Fenclofenac
Gold salts
Penicillamine
Phenytoin
Sulfasalazine
Genetic Disorders
Ataxia Telangiectasia
Autosomal forms of SCID
Hyper IgM Immunodeficiency
Transcobalamin II deficiency and hypogammaglobulinemia
X-linked agammaglobulinemia
X-linked lymphoproliferative disorder (EBV associated)
X-linked SCID
Some metabolic disorders
Chromosomal Anomalies
Chromosome 18q- Syndrome
Monosomy 22
Trisomy 8
Trisomy 21
Infectious Diseases
HIV
Congenital Rubella
Congenital infection with CMV
Congenital infection with Toxoplasma gondii
Epstein-Barr Virus
Malignancy
Chronic Lymphocytic Leukemia
Immunodeficiency with Thymoma
Non Hodgkin's lymphoma
B cell malignancy
Systemic Disorders
Immunodeficiency caused by hypercatabolism of immunoglobulin
Immunodeficiency caused by excessive loss of immunoglobulins (nephrosis, severe burns, lymphangiectasia, severe diarrhea)